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JEANNE F. LORING, PH.D.
Adjunct Professor
Stem Cells and Regenerative Biology
Professor of Developmental Neurobiology
Director, Center for Regenerative Medicine
The Scripps Research Institute
RESEARCH FOCUS, BIOGRAPHY, PUBLICATIONS
Research Focus
Dr. Loring's current research focuses on the molecular basis of pluripotence and differentiation of human embryonic stem (ES) cells. Her laboratory studies human ES cells using gene expression profiling, SNP genotyping, DNA methylation and other high information content approaches to understand how pluripotence is maintained, and how to direct differentiation along specific pathways.
Biography
Dr. Jeanne Loring has a B.S. in Molecular Biology and a Ph.D. in Developmental Neurobiology. She was on the faculty of the University of California at Davis, and has held research and management positions at biotechnology companies including Hana Biologics, GenPharm International, Incyte Genomics, and Arcos BioScience. She joined the faculty of the Burnham Institute for Medical Research as a principal investigator in January 2004 and served as Director of the Human Stem Cell Resource and the NIH Human Embryonic Stem Cell Training Course and Co-Director of the institute's NIH Exploratory Center for Human Embryonic Stem Cell Research. In 2007, Dr. Loring joined The Scripps Research Institute as Professor of Developmental Neurobiology.
Selected Publications
D.K. Hanzel, J.Q.Trojanowski, R.F. Johnston, and J.F. Loring (1999). High-throughput quantitative histological analysis by a confocal digital microscanner: Application to Alzheimer’s disease pathology. Nature Biotechnology 17: 53-57.
Loring, J.F. (1999). Design of animal models of Alzheimer’s disease with amyloid precursor protein transgenes. In: Ed. Nigel Hooper, Alzheimer's Disease: Methods and Protocols (Methods in Molecular Medicine Series). Humana Press.
Loring, J.F. J.G. Porter, MR Kaser, J. Seilhamer, R Wesselschmidt (2001). Gene expression profile of embryonic stem cells. Restorative Neurology and Neuroscience 18:81-88.
Loring, J. F., Wen, X., Lee, J. M., Seilhamer, J. & Somogyi, R. (2001) A gene expression profile of Alzheimer's disease. DNA Cell Biol 20, 683-95.
Dickey, C.A., J. F. Loring, J. Montgomery, M.N. Gordon, P.S. Eastman & D. Morgan (2003) Selectively reduced expression of synaptic plasticity-related genes in APP+PS1 Transgenic Mice. J.Neuroscience 23:5219
Loring, J.F. (2005) Sharing stem cell information. The Scientist, July, 2005.
Loring JF, Rao MS. (2006). Establishing standards for the characterization of embryonic stem cell lines. Stem Cells. 24:145-50.
Muller FJ, Snyder EY, Loring JF. 2006. Gene therapy: can neural stem cells deliver? Nat Rev Neurosci 7:75-84.
Loring JF and Campbell C. (2006). Science and law. Intellectual property and human embryonic stem cell research. Science. 311:1716-7.
Huai Li, Liu Y, Shin S, Sun Y, Loring JF, Mattson MP, Rao MS, Zhan M (2006). Transcriptome coexpression map of human embryonic stem cells. BMC Genomics 7:103.
Bibikova, M, E Chudin, B Wu, L Zhou, El Wickham Garcia, Y Liu, S Shin, TW. Plaia3, JM. Auerbach, DE. Arking, R Gonzalez, J Crook, B Davidson, TC. Schulz, A Robins, A Khanna, P Sartipy, J Hyllner, P Vanguri, S Savant- Bhonsale, AK. Smith, A Chakravarti , A Maitra, M Rao, DL. Barker, JF. Loring and J-B Fan. (2006). Human Embryonic Stem Cells Have a Unique Epigenetic Signature. In Press, Genome Research.
Loring, JF, P Schwartz, R Wesselschmidt. Human Stem Cell Manual: A Laboratory Guide; Elsevier Press, 2006 (in press).
List of Publications via PubMed
(NIH National Library of Medicine)
