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GREGORY P. ROTH, PH.D.
Associate Professor
Director of Medicinal Chemistry
Conrad Prebys Center for Chemical Genomics
Primary Appointment:
Diabetes and Obesity Center: Cardiovascular Pathobiology
Cancer Center: Signal Transduction Program
407.745.2062 (phone)
407.745.2001 (fax)
Mailing Address
groth@burnham.org
RESEARCH FOCUS, BIOGRAPHY, STAFF, PUBLICATIONS
Research Focus
Gregory P. Roth, Associate professor and Director of Medicinal Chemistry at Burnham Institute for Medical Research at Lake Nona, has over 20 years of post-graduate pharmaceutical industry leadership and scientific accomplishments in the areas of Process Research, Combinatorial Chemistry, and Medicinal Chemistry. Roth’s research interests focus on advancing novel synthetic methods and technologies for the generation of compound screening libraries based on natural product motifs.
Roth’s current work centers on chemical biology and medicinal chemistry in the areas of inflammatory disease and cancer. Roth leads the Burnham collaboration with researchers at the Harbor Branch Oceanographic Institute, in creating synthetic anti-cancer compounds that are based on biologically-active, naturally occurring compounds found in sponges. Roth’s lab is developing methods to develop new, enhanced analogs of a newly discovered molecule, aphrocallistin, which demonstrates properties that may be beneficial to the treatment of specific cancer types.
Biography
Dr. Roth holds 14 patents and he has authored more than 40 research papers. Roth earned a Doctorate of Philosophy in Chemistry at Colorado State University in 1988 and a Master of Science in Chemistry at State University of New York at Fredonia in 1984. Prior to joining Burnham, Roth contributed to a variety of research programs at Bristol-Myers Squibb, Boehringer Ingelheim Pharmaceuticals and the Abbott Bioresearch Center.
Selected Publications
“Lead Identification of 2-Iminobenzimidazole Antagonists of the Chemokine Receptor CXCR3” Hayes, M.E.; Breinlinger, E.C.; Wallace, G.A.; Grongsaard, P.; Miao, W.; McPherson, M.J.; Stoffel, R.; Green, D.W.; Roth, G.P. Bioorg. Med. Chem. Lett. 2008, 18, 2414-2419.
“Discovery of Small Molecule Benzimidazole Antagonists of the Chemokine Receptor CXCR3” Hayes, M.E.; Wallace, G.A.; Grongsaard, P.; Bischoff, A.; George, D.M.; Miao, W.; McPherson, M.J.; Stoffel, R.; Green, D.W.; Roth, G.P. Bioorg. Med. Chem. Lett. 2008, 18, 1573-1576.
“Hit to Lead Studies on Benzimidazole Inhibitors of ITK: Discovery of a novel Class of Kinase Inhibitor” R.J. Snow, A. Abeywardane, S. Campbell, J. Lord, M.A. Kashem, H.H. Khine, J. King, J.A. Kowalski, S.S. Pullen, T. Roma, G.P. Roth, C.R. Sarko, N.S. Wilson, M. Winters, J.P. Wolak, and C.L. Cywin Bioorg. Med. Chem. Lett. 2007, 17, 3660-3665.
“Overview: Differentiating Issues in the Development of Macromolecules Compared with Small Molecules” G. Blaich, B. Janssen, G.P. Roth, and J. Salfeld In: Handbook of Pharmaceutical Biotechnology, J.P. Rho, S. Louie, Eds., John Wiley and Sons, Inc, 2007, 97-134.
"Asthma and COPD" G.P. Roth and D.W. Green In: Comprehensive Medicinal Chemistry II, Vol. 7, D.J. Triggle and J.B. Taylor, Eds., Elsevier: Oxford, 2006, 873-916.
“Development and Applications of a Practical Continuous Microwave Flow Cell” N.S. Wilson, C.R. Sarko and G.P. Roth Organic Process Research and Development, 2004, 8, 535.
“Recent Trends in Microwave Assisted Synthesis” N.S. Wilson and G.P. Roth Current Opinion in Drug Discovery and Development 2002, 5, 620.
“Combinatorial Synthesis of Natural Product-like Molecules using a Spiroketal Scaffold” B.A. Kulkarni, G.P. Roth, E. Lobkovsky, and J.A. Porco Jr. J. Combinatorial Chem. 2002, 4, 56.
“Microwave-Assisted Synthesis of 2-Aminoquinolines” N.S. Wilson, C.R. Sarko and G.P. Roth Tetrahedron Letters 2002, 43, 581.
List of Publications via PubMed
(NIH National Library of Medicine)
