Publications
|
| 2008
Publications |
Snipas
SJ, Drag M, Stennicke
HR, Salvesen GS.
Activation mechanism and
substrate specificity of the Drosophila initiator caspase DRONC.
Cell Death Differ. 2008 Feb 29;
PMID: 18309328 |
Eckelman
BP, Drag M, Snipas SJ, Salvesen GS.
The mechanism of
peptide-binding specificity of IAP BIR domains.
Cell Death Differ. 2008 Feb 1;
PMID: 18239672 |
Denault JB, Salvesen GS.
Apoptotic caspase
activation and activity.
Methods Mol Biol. 2008;414:191-220. Review.
PMID: 18175821 |
McStay GP, Salvesen GS, Green DR.
Overlapping cleavage motif
selectivity of caspases: implications for analysis of apoptotic
pathways.
Cell Death Differ. 2008 Feb;15(2):322-31.
PMID: 17975551 |
Drag
M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS.
Activity profiling of
human
deSUMOylating enzymes (SENPs) with synthetic substrates suggests an
unexpected specificity of two newly characterized members of the family.
Biochem J. 2008 Jan 15;409(2):461-9.
PMID: 17916063 |
| 2007
Publications |
Denault
JB, Drag M, Salvesen GS, Alves J, Heidt AB,
Deveraux Q, Harris JL.
Small molecules not direct
activators of caspases.
Nat Chem Biol. 2007 Sep;3(9):519; author reply 520. N
PMID: 17710090 |
Truscott M, Denault JB, Goulet B, Leduy L, Salvesen GS, Nepveu
A.
Carboxy-terminal
proteolytic processing of CUX1 by a caspase enables
transcriptional activation in proliferating cells.
J Biol Chem. 2007 Aug 6;
PMID: 17681953 |
Wu YI, Munshi HG, Snipas SJ, Salvesen GS, Fridman R, Stack
MS.
Activation-coupled
membrane-type
1 matrix metalloproteinase membrane trafficking.
Biochem J. 2007 Oct 15;407(2):171-7.
PMID: 17650075 |
Timmer
JC, Enoksson M, Wildfang E, Zhu W, Igarashi Y, Denault JB, Ma Y, Dummitt B, Chang
YH, Mast AE, Eroshkin A, Smith JW, Tao WA, Salvesen GS.
Profiling constitutive
proteolytic events in vivo.
Biochem J. 2007 Oct 1;407(1):41-8.
PMID: 17650073 |
Mikolajczyk
J, Drag M, Bekes M, Cao JT, Ronai Z, Salvesen GS.
Small Ubiquitin-related
Modifier
(SUMO)-specific Proteases: PROFILING THE SPECIFICITIES AND ACTIVITIES
OF HUMAN SENPs.
J Biol Chem. 2007 Sep 7;282(36):26217-24. Epub 2007 Jun 25.
PMID: 17591783 |
Enoksson
M, Li J, Ivancic MM, Timmer JC,
Wildfang E, Eroshkin A, Salvesen GS, Tao
WA.
Identification of
Proteolytic Cleavage Sites by Quantitative Proteomics.
J Proteome Res. 2007 Jun 5;
PMID: 17547438 |
Riedl SJ, Salvesen GS.
The apoptosome:
signalling platform of cell death.
Nat Rev Mol Cell Biol. 2007 Mar 21;
PMID: 17377525
|
Pop
C, Fitzgerald P, Green DR, Salvesen
GS.
Role of
Proteolysis in Caspase-8 Activation and Stabilization.
Biochemistry. 2007 Mar 20;
PMID: 17371051
|
2006
Publications
|
Timmer
JC, Salvesen GS.
Caspase substrates.
Cell Death Differ. 2006 Nov 3;
PMID: 17082814
|
Dobo J, Swanson R, Salvesen GS, Olson ST, Gettins
PG.
CrmA inhibition of
initiator caspases results in covalent complex
formation and dissociation of the caspase tetramer.
J Biol Chem. 2006 Oct 19;
PMID: 17052983
|
Eckelman
BP, Salvesen GS, Scott FL. Related Articles,
Links
Human inhibitor of
apoptosis
proteins: why XIAP is the black sheep of
the family.
EMBO Rep. 2006 Oct;7(10):988-94.
PMID: 17016456
|
Ekici OD, Li ZZ, Campbell AJ,
James KE, Asgian JL, Mikolajczyk J,
Salvesen GS, Ganesan R,
Jelakovic S, Grutter MG, Powers JC.
Design, synthesis, and
evaluation of
aza-peptide Michael acceptors as
selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and
-10.
J Med Chem. 2006 Sep 21;49(19):5728-49.
PMID: 16970398
|
Denault
JB, Bekes M, Scott FL, Sexton KM, Bogyo M, Salvesen GS.
Engineered hybrid dimers:
tracking the activation pathway of caspase-7.
Mol Cell. 2006 Aug;23(4):523-33.
PMID: 16916640
|
Berger AB, Witte MD, Denault JB, Sadaghiani AM, Sexton
KM, Salvesen GS, Bogyo
M.
Identification of early
intermediates of caspase activation using
selective inhibitors and activity-based probes.
Mol Cell. 2006 Aug;23(4):509-21.
PMID: 16916639
|
Pop
C, Timmer J, Sperandio S, Salvesen GS.
The apoptosome activates
caspase-9 by dimerization.
Mol Cell.
2006 Apr 21;22(2):269-75.
PMID: 16630894
|
Brendan
P. Eckelman and Guy S. Salvesen
The Human Anti-apoptotic
Proteins
cIAP1 and cIAP2 Bind but Do Not
Inhibit Caspases
J. Biol. Chem. 2006 281: 3254-3260. First Published on December
8, 2005; doi:10.1074/jbc.M510863200
|
2005
Publications
|
Maryla
Krajewska, Hoguen Kim, Eunah Shin, Susan Kennedy, Michael J. Duffy,
Yick F. Wong, David Marr, Jowita
Mikolajczyk, Ahmed Shabaik, Ivo
Meinhold-Heerlein, Xianshu Huang, Steven Banares, Hirad Hedayat, John
C. Reed, and Stan Krajewski
Tumor-Associated
Alterations in Caspase-14 Expression in Epithelial Malignancies
Clin Cancer Res 2005 11: 5462-5471. |
Simonovic
M, Denault JB, Salvesen GS, Volz K, Gettins PG.
Lack of involvement
of
strand s1'A of the viral serpin CrmA in anti-apoptotic or
caspase-inhibitory functions.
Arch Biochem Biophys.
2005 Aug 1;440(1):1-9.
PMID: 15993378 |
Fiona L Scott,
Jean-Bernard Denault, Stefan J Riedl, Hwain Shin, Martin Renatus, and Guy S Salvesen
XIAP
inhibits caspase-3 and
-7 using two binding sites: evolutionarily conserved mechanism of IAPs
EMBO J., Feb 2005; 24: 645 - 655. |
|
| 2004
Publications |
Snipas SJ,Wildfang E, Nazif T,
Christensen
L,Boatright KM,Bogyo M,Stennicke HR, Salvesen GS.
Characteristics of the
caspase-like catalytic domain of human
paracaspase.
Biological Chemistry 2004 Nov;385 1093-1098.
|
Vucic
D, Franklin
MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO,
Kadkhodayan
S, Deshayes K, Salvesen G,
Fairbrother WJ.
Engineering ML-IAP to
produce
an extraordinarily potent caspase-9
inhibitor:
implications for Smac-dependent anti-apoptotic activity of ML-IAP.
Biochem J.
2004 Oct 15
PMID: 15485396
|
Shin H, Renatus M, Eckelman BP, Nunes VA, Sampaio CA, Salvesen GS.
The BIR domain of IAP-like
protein 2 is conformationally unstable:
implications
for caspase inhibition.
Biochem J.
2004 Oct 15
PMID: 15485395
|
Fuentes-Prior
P, Salvesen
GS.
The protein structures
that
shape caspase-activity, specificity,
activation,
and inhibition.
Biochem J.
2004 Sep 27; Pt
PMID: 15450003
|
Krajewska M, Rosenthal RE, Mikolajczyk J, Stennicke HR, Wiesenthal T, Mai J,
Naito
M, Salvesen GS, Reed JC,
Fiskum G,
Krajewski S.
Early processing of Bid
and
caspase-6, -8, -10, -14 in the canine brain
during
cardiac arrest and resuscitation.
Exp Neurol. 2004
Oct;189(2):261-79.
PMID: 15380478
|
Wilkinson JC, Wilkinson AS, Scott FL, Csomos RA, Salvesen GS, Duckett CS.
Neutralization of
Smac/Diablo
by IAPs: a caspase-independent mechanism for apoptotic inhibition.
J Biol
Chem.
2004 Sep 15
PMID: 15371416
|
Mikolajczyk
J, Scott FL, Krajewski
S,
Sutherlin DP, Salvesen GS.
Activation and substrate
specificity
of caspase-14.
Biochemistry. 2004 Aug
17;43(32):10560-9.
PMID: 15301553
|
Dohi
T, Okada K, Xia F, Wilford CE, Samuel T, Welsh K, Marusawa H, Zou H,
Armstrong
R, Matsuzawa S, Salvesen GS, Reed JC, Altieri DC.
An IAP-IAP complex
inhibits
apoptosis.
J Biol
Chem.
2004 Aug 13;279(33):34087-90.
PMID: 15218035
|
Boatright
KM, Deis C, Denault JB, Sutherlin DP, Salvesen GS.
Activation of caspases-8
and -10
by FLIP(L).
Biochem J. 2004 Sep 1;382(Pt
2):651-7.
PMID: 15209560
|
Salvesen
GS, Abrams JM.
Caspase activation -
stepping on
the gas or releasing the brakes?
Lessons
from humans and flies.
Oncogene. 2004 Apr
12;23(16):2774-84.
Review.
PMID: 15077141
|
Denault
JB, Boatright K.
Apoptosis in Biochemistry
and Structural Biology.
3-8 February 2004,
Keystone,
CO, USA.
IDrugs. 2004 Apr;7(4):315-7.
PMID: 15057633 |
Ekici OD, Gotz MG, James KE, Li
ZZ,
Rukamp BJ, Asgian JL, Caffrey CR, Hansell E, Dvorak J, McKerrow JH,
Potempa
J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC.
Aza-peptide Michael
acceptors: a
new class of inhibitors specific for
caspases
and other clan CD cysteine proteases.
J Med Chem. 2004 Apr
8;47(8):1889-92.
PMID: 15055989
|
James KE, Asgian JL, Li ZZ,
Ekici
OD, Rubin JR, Mikolajczyk J, Salvesen GS, Powers JC.
Design, synthesis, and
evaluation
of aza-peptide epoxides as selective
and
potent inhibitors of caspases-1, -3, -6, and -8.
J Med Chem. 2004 Mar
11;47(6):1553-74.
PMID: 14998341
|
Pedersen IM, Zapata JM, Samuel
T, Scott FL, Salvesen GS, Honda T, Gribble GW,
Suh
N, Sporn MB, Kipps TJ, Reed JC.
Retraction: The
triterpenoid
CDDO-Imidazolide induces apoptosis and
enhances
fludarabine-induced apoptosis of CLL B-cells.
Blood. 2004 Aug 15;104(4):932.
Epub
2004 Jan 22. No abstract available.
PMID: 14739219
|
Wu YI, Munshi HG, Sen R, Snipas SJ, Salvesen GS, Fridman R, Stack MS.
Glycosylation broadens the
substrate profile of membrane type 1 matrix
metalloproteinase.
J Biol Chem. 2004 Feb
27;279(9):8278-89.
PMID: 14670950
|
Cirman T, Oresic K, Mazovec GD,
Turk
V, Reed JC, Myers RM, Salvesen GS,
Turk B.
Selective disruption of
lysosomes
in HeLa cells triggers apoptosis
mediated
by cleavage of Bid by multiple papain-like lysosomal cathepsins.
J Biol Chem. 2004 Jan
30;279(5):3578-87.
PMID: 14581476 |
| 2003
Publications |
Boatright
KM, Salvesen GS.
Mechanisms of caspase
activation.
Curr Opin Cell Biol. 2003
Dec;15(6):725-31.
Review.
PMID: 14644197
|
Boatright
KM, Salvesen GS.
Caspase activation.
Biochem Soc Symp.
2003(70):233-42.
Review.
PMID: 14587296
|
Ryan
CA, Salvesen GS.
Caspases and neuronal
development.
Biol Chem. 2003 Jun;384(6):855-61. Review.
PMID: 12887052
|
Kashkar H, Haefs C, Shin H, Hamilton-Dutoit SJ, Salvesen GS, Kronke M, Jurgensmeier
JM.
XIAP-mediated caspase
inhibition
in Hodgkin's lymphoma-derived B cells.
J Exp Med. 2003 Jul
21;198(2):341-7.
PMID: 12874265
|
Denault
JB, Salvesen GS.
Human caspase-7 activity
and
regulation by its N-terminal peptide.
J Biol Chem. 2003 Sep
5;278(36):34042-50.
PMID: 12824163
|
Shin
H, Okada K, Wilkinson JC, Solomon KM, Duckett CS, Reed JC, Salvesen GS.
Identification of
ubiquitination
sites on the X-linked inhibitor of
apoptosis
protein.
Biochem J. 2003 Aug 1;373(Pt
3):965-71.
PMID: 12747801
|
Salvesen
GS, Scott FL.
Serpins are getting hotter.
Structure (Camb). 2003
Apr;11(4):364-5.
No abstract available.
PMID: 12679013
|
Boatright
KM, Renatus M, Scott FL, Sperandio S, Shin H, Pedersen IM, Ricci JE, Edris
WA,
Sutherlin DP, Green DR, Salvesen GS.
A unified model for apical
caspase
activation.
Mol Cell. 2003 Feb;11(2):529-41.
PMID: 12620239
|
Mikolajczyk
J, Boatright KM, Stennicke HR, Nazif T, Potempa J,
Bogyo
M, Salvesen GS.
Sequential autolytic
processing
activates the zymogen of Arg-gingipain.
J Biol Chem. 2003 Mar 21;278(12):10458-64. Epub 2003 Jan 17.
PMID: 12533545
|
| 2002
Publications |
Denault
JB, Salvesen GS.
Caspases: keys in the
ignition of cell death.
Chem Rev. 2002
Dec;102(12):4489-500.
Review. No abstract available.
PMID: 12475198
|
Salvesen
GS.
Caspases and apoptosis.
Essays Biochem. 2002;38:9-19.
Review.
PMID: 12463158
|
Asgian JL, James KE, Li ZZ,
Carter
W, Barrett AJ, Mikolajczyk J, Salvesen GS, Powers JC.
Aza-peptide epoxides: a
new class
of inhibitors selective for clan CD
cysteine
proteases.
J Med Chem. 2002 Nov
7;45(23):4958-60.
PMID: 12408706
|
Turk B, Turk D, Salvesen GS.
Regulating cysteine
protease activity: essential role of protease
inhibitors
as guardians and regulators.
Curr Pharm Des.
2002;8(18):1623-37.
Review.
PMID: 12132995
|
Troy CM, Salvesen GS.
Caspases on the brain.
J Neurosci Res. 2002 Jul
15;69(2):145-50.
Review.
PMID: 12111795
|
Ryan
CA, Stennicke HR, Nava
VE, Burch JB, Hardwick JM, Salvesen GS.
Inhibitor specificity of
recombinant and endogenous caspase-9.
Biochem J. 2002 Sep 1;366(Pt
2):595-601.
PMID: 12067274
|
Salvesen
GS, Duckett CS.
IAP proteins: blocking the
road
to death's door.
Nat Rev Mol Cell Biol. 2002
Jun;3(6):401-10.
Review.
PMID: 12042762
|
Lu C, Fu W, Salvesen GS, Mattson MP.
Direct cleavage of AMPA
receptor subunit GluR1 and suppression of AMPA
currents
by caspase-3: implications for synaptic plasticity and excitotoxic
neuronal
death.
Neuromolecular Med.
2002;1(1):69-79.
PMID: 12025817
|
Gil-Parrado
S, Fernandez-Montalvan A, Assfalg-Machleidt I, Popp O, Bestvater
F, Holloschi A, Knoch TA, Auerswald EA, Welsh K, Reed JC, Fritz H,
Fuentes-Prior
P, Spiess E, Salvesen GS,
Machleidt
W.
Ionomycin-activated
calpain triggers apoptosis. A probable role for
Bcl-2
family members.
J Biol Chem. 2002 Jul
26;277(30):27217-26.
PMID: 12000759
|
Okamoto S, Li Z, Ju C, Scholzke
MN,
Mathews E, Cui J, Salvesen GS,
Bossy-Wetzel
E, Lipton SA.
Dominant-interfering
forms of MEF2 generated by caspase cleavage
contribute
to NMDA-induced neuronal apoptosis.
Proc Natl Acad Sci U S A. 2002
Mar
19;99(6):3974-9.
PMID: 11904443
|
Salvesen
GS, Renatus M.
Apoptosome: the
seven-spoked death machine.
Dev Cell. 2002 Mar;2(3):256-7.
Review.
PMID: 11879630
|
Stennicke
HR, Ryan CA, Salvesen GS.
Reprieval from
execution: the molecular basis of caspase inhibition.
Trends Biochem Sci. 2002 Feb;27(2):94-101. Review.
PMID: 11852247
|
Salvesen
GS.
Caspases: opening the
boxes
and interpreting the arrows.
Cell Death Differ. 2002
Jan;9(1):3-5.
No abstract available.
PMID: 11803369
|
| 2001
Publications |
Riedl
SJ, Fuentes-Prior P, Renatus M,
Kairies N, Krapp S, Huber R, Salvesen
GS, Bode W.
Structural basis for the
activation of human procaspase-7.
Proc Natl Acad Sci U S A. 2001
Dec
18;98(26):14790-5.
PMID: 11752425
|
Renatus
M, Stennicke HR, Scott FL, Liddington RC, Salvesen GS.
Dimer formation drives the
activation of the cell death protease
caspase
9.
Proc Natl Acad Sci U S A. 2001
Dec
4;98(25):14250-5.
PMID: 11734640
|
Riedl
SJ, Renatus M, Snipas SJ, Salvesen GS.
Mechanism-based
inactivation of
caspases by the apoptotic suppressor
p35.
Biochemistry. 2001 Nov
6;40(44):13274-80.
PMID: 11683637
|
Snipas
SJ, Stennicke HR, Riedl S, Potempa J, Travis J,
Barrett
AJ, Salvesen GS.
Inhibition of distant
caspase
homologues by natural caspase inhibitors.
Biochem J. 2001 Jul 15;357(Pt
2):575-80.
PMID: 11439111
|
Silverman GA, Bird PI, Carrell
RW,
Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer
RW,
Pemberton PA, Remold-O'Donnell E, Salvesen
GS, Travis J, Whisstock JC.
The serpins are an
expanding superfamily of structurally similar but
functionally
diverse proteins. Evolution, mechanism of inhibition, novel functions,
and
a revised nomenclature.
J Biol Chem. 2001 Sep
7;276(36):33293-6.
Epub 2001 Jul 02. Review. No abstract available.
PMID: 11435447
|
Riedl
SJ, Renatus M,
Schwarzenbacher
R, Zhou Q, Sun C, Fesik SW,
Liddington
RC, Salvesen GS.
Structural basis for the
inhibition of caspase-3 by XIAP.
Cell. 2001 Mar 9;104(5):791-800.
PMID: 11257232
|
Salvesen
GS.
A lysosomal protease
enters
the death scene.
J Clin Invest. 2001
Jan;107(1):21-2.
Review. No abstract available.
PMID: 11134173
|
Leo E, Deveraux QL, Buchholtz C,
Welsh
K, Matsuzawa S, Stennicke HR, Salvesen GS, Reed JC.
TRAF1 is a substrate of
caspases activated during tumor necrosis factor
receptor-alpha-induced
apoptosis.
J Biol Chem. 2001 Mar
16;276(11):8087-93.
PMID: 11098060
|
Stoka V, Turk B, Schendel
SL, Kim TH, Cirman T, Snipas SJ,
Ellerby
LM, Bredesen D, Freeze H, Abrahamson M, Bromme D, Krajewski S, Reed JC,
Yin
XM, Turk V, Salvesen GS.
Lysosomal protease
pathways to
apoptosis. Cleavage of bid, not
pro-caspases,
is the most likely route.
J Biol Chem. 2001 Feb
2;276(5):3149-57.
PMID: 11073962
|
Affar EB, Germain M, Winstall E,
Vodenicharov
M, Shah RG, Salvesen GS,
Poirier
GG.
Caspase-3-mediated
processing of poly(ADP-ribose) glycohydrolase during
apoptosis.
J Biol Chem. 2001 Jan
26;276(4):2935-42.
PMID: 11053413
|
| 2000
Publications |
Vucic D, Stennicke HR, Pisabarro MT, Salvesen GS, Dixit VM.
ML-IAP, a novel
inhibitor of apoptosis that is preferentially expressed
in
human melanomas.
Curr Biol. 2000 Nov
2;10(21):1359-66.
PMID: 11084335 |
Stennicke
HR, Renatus M, Meldal
M, Salvesen GS.
Internally quenched
fluorescent peptide substrates disclose the subsite
preferences
of human caspases 1, 3, 6, 7 and 8.
Biochem J. 2000 Sep 1;350 Pt 2:563-8.
PMID: 10947972
|
Zhou
Q, Salvesen GS.
Viral caspase inhibitors
CrmA and p35.
Methods Enzymol.
2000;322:143-54.
No abstract available.
PMID: 10914011
|
Stennicke
HR, Salvesen GS.
Caspase assays.
Methods Enzymol.
2000;322:91-100.
No abstract available.
PMID: 10914007
|
Renatus
M, Zhou Q, Stennicke HR, Snipas SJ, Turk D, Bankston LA,
Liddington
RC, Salvesen GS.
Crystal structure of the
apoptotic
suppressor CrmA in its cleaved form.
Structure Fold Des. 2000 Jul
15;8(7):789-97.
PMID: 10903953
|
Lu DC, Rabizadeh S, Chandra S,
Shayya
RF, Ellerby LM, Ye X, Salvesen GS,
Koo EH, Bredesen DE.
A second cytotoxic
proteolytic peptide derived from amyloid
beta-protein
precursor.
Nat Med. 2000 Apr;6(4):397-404.
PMID: 10742146
|
Stennicke
HR, Salvesen GS.
Caspases -
controlling intracellular signals by protease zymogen
activation.
Biochim Biophys Acta. 2000 Mar
7;1477(1-2):299-306.
Review.
PMID: 10708865
|
Huang Q, Deveraux QL, Maeda S, Salvesen GS, Stennicke HR, Hammock BD, Reed JC.
Evolutionary
conservation of apoptosis mechanisms: lepidopteran and
baculoviral
inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9.
Proc Natl Acad Sci U S A. 2000
Feb
15;97(4):1427-32.
PMID: 10677478
|
| 1999
Publications |
Deveraux QL, Stennicke HR, Salvesen GS, Reed JC.
Endogenous inhibitors
of caspases.
J Clin Immunol. 1999
Nov;19(6):388-98.
Review.
PMID: 10634212
|
Stennicke
HR, Salvesen GS.
Catalytic properties
of the caspases.
Cell Death Differ. 1999
Nov;6(11):1054-9.
Review.
PMID: 10578173
|
Salvesen
GS.
Caspase 8: igniting the
death machine.
Structure Fold Des. 1999 Oct
15;7(10):R225-9.
Review.
PMID: 10545333
|
Deveraux QL, Leo E, Stennicke HR, Welsh K, Salvesen GS, Reed JC.
Cleavage of human
inhibitor
of apoptosis protein XIAP results in
fragments
with distinct specificities for caspases.
EMBO J. 1999 Oct
1;18(19):5242-51.
PMID: 10508158
|
Salvesen
GS, Dixit VM.
Caspase activation: the
induced-proximity model.
Proc Natl Acad Sci U S A. 1999
Sep
28;96(20):10964-7. Review.
PMID: 10500109
|
Germain M, Affar EB, D'Amours D,
Dixit
VM, Salvesen GS, Poirier GG.
Cleavage of
automodified poly(ADP-ribose) polymerase during apoptosis.
Evidence
for involvement of caspase-7.
J Biol Chem. 1999 Oct
1;274(40):28379-84.
PMID: 10497198
|
Wolf BB, Goldstein JC, Stennicke HR, Beere H,
Amarante-Mendes
GP, Salvesen GS, Green DR.
Calpain functions in a
caspase-independent manner to promote
apoptosis-like
events during platelet activation.
Blood. 1999 Sep 1;94(5):1683-92.
PMID: 10477693
|
Krajewski S, Krajewska M,
Ellerby
LM, Welsh K, Xie Z, Deveraux QL, Salvesen
GS, Bredesen DE, Rosenthal RE, Fiskum G, Reed JC.
Release of caspase-9
from mitochondria during neuronal apoptosis and
cerebral
ischemia.
Proc Natl Acad Sci U S A. 1999
May
11;96(10):5752-7.
PMID: 10318956
|
Stennicke
HR, Salvesen GS.
Caspases:
preparation and characterization.
Methods. 1999 Apr;17(4):313-9.
PMID: 10196102
|
Salvesen
GS.
Programmed cell death and
the caspases.
APMIS. 1999 Jan;107(1):73-9.
Review.
PMID: 10190282
|
Chou JJ, Li H, Salvesen GS, Yuan J, Wagner G.
Solution structure of
BID, an intracellular amplifier of apoptotic
signaling.
Cell. 1999 Mar 5;96(5):615-24.
PMID: 10089877
|
Ellerby LM, Andrusiak RL,
Wellington
CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR, Bredesen DE.
Cleavage of atrophin-1 at
caspase site aspartic acid 109 modulates
cytotoxicity.
J Biol Chem. 1999 Mar
26;274(13):8730-6.
PMID: 10085113
|
Stennicke
HR, Deveraux QL, Humke EW, Reed JC, Dixit VM, Salvesen GS.
Caspase-9 can be
activated without proteolytic processing.
J Biol Chem. 1999 Mar
26;274(13):8359-62.
PMID: 10085063
|
Ellerby LM, Hackam AS, Propp SS,
Ellerby
HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE.
Kennedy's
disease: caspase cleavage of the androgen receptor is a
crucial
event in cytotoxicity.
J Neurochem. 1999
Jan;72(1):185-95.
PMID: 9886069 |
| 1998
Publications |
Amarante-Mendes GP, Finucane DM,
Martin
SJ, Cotter TG, Salvesen GS,
Green
DR.
Anti-apoptotic oncogenes
prevent caspase-dependent and independent
commitment
for cell death.
Cell Death Differ. 1998
Apr;5(4):298-306.
PMID: 10200475 |
Miyashita T, Nagao K, Krajewski
S, Salvesen GS, Reed JC, Inoue
T, Yamada M.
Investigation of
glucocorticoid-induced apoptotic pathway: processing
of
caspase-6 but not caspase-3.
Cell Death Differ. 1998
Dec;5(12):1034-41.
PMID: 9894610
|
Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM.
Caspase-14 is a novel
developmentally regulated protease.
J Biol Chem. 1998 Nov
6;273(45):29648-53.
PMID: 9792675
|
Yang X, Stennicke HR, Wang B, Green DR,
Janicke
RU, Srinivasan A, Seth P, Salvesen GS,
Froelich CJ.
Granzyme B mimics apical
caspases. Description of a unified pathway for
trans-activation
of executioner caspase-3 and -7.
J Biol Chem. 1998 Dec
18;273(51):34278-83.
PMID: 9852092
|
Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge
E,
Frisch S, Reed JC.
Regulation of cell
death protease caspase-9 by phosphorylation.
Science. 1998 Nov
13;282(5392):1318-21.
PMID: 9812896
|
Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS, Bredesen DE.
The DCC gene product
induces
apoptosis by a mechanism requiring
receptor
proteolysis.
Nature. 1998 Oct
22;395(6704):801-4.
PMID: 9796814
|
Stennicke
HR, Jurgensmeier JM, Shin H,
Deveraux Q, Wolf BB, Yang X, Zhou Q,
Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen GS.
Pro-caspase-3 is a
major physiologic target of caspase-8.
J Biol Chem. 1998 Oct
16;273(42):27084-90.
PMID: 9765224
|
Stennicke
HR, Salvesen GS.
Properties of the
caspases.
Biochim Biophys Acta. 1998 Sep
8;1387(1-2):17-31.
Review.
PMID: 9748481
|
Zhou
Q, Krebs JF, Snipas SJ,
Price
A, Alnemri ES, Tomaselli KJ, Salvesen
GS.
Interaction of the
baculovirus
anti-apoptotic protein p35 with
caspases.
Specificity, kinetics, and characterization of the caspase/p35 complex.
Biochemistry. 1998 Jul
28;37(30):10757-65.
PMID: 9692966
|
Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC.
IAPs block apoptotic
events induced by caspase-8 and cytochrome c by
direct
inhibition of distinct caspases.
EMBO J. 1998 Apr
15;17(8):2215-23.
PMID: 9545235
|
Wellington CL, Ellerby LM,
Hackam
AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M,
Rowland
KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross
CA,
Nicholson DW, Bredesen DE, Hayden MR.
Caspase cleavage of
gene products associated with triplet expansion
disorders
generates truncated fragments containing the polyglutamine tract.
J Biol Chem. 1998 Apr
10;273(15):9158-67.
PMID: 9535906
|
Takahashi R, Deveraux Q, Tamm I,
Welsh
K, Assa-Munt N, Salvesen GS,
Reed
JC.
A single BIR domain
of XIAP sufficient for inhibiting caspases.
J Biol Chem. 1998 Apr
3;273(14):7787-90.
PMID: 9525868
|
Zapata JM, Takahashi R, Salvesen GS, Reed JC.
Granzyme release and
caspase activation in activated human
T-lymphocytes.
J Biol Chem. 1998 Mar
20;273(12):6916-20.
PMID: 9506996
|
Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM.
An induced proximity
model for caspase-8 activation.
J Biol Chem. 1998 Jan
30;273(5):2926-30.
PMID: 9446604
|
| 1997
Publications |
Roy N, Deveraux QL, Takahashi R,
Salvesen GS, Reed JC.
The c-IAP-1 and c-IAP-2
proteins are direct inhibitors of specific
caspases.
EMBO J. 1997 Dec
1;16(23):6914-25.
PMID: 9384571
|
Salvesen
GS.
Serpins and programmed
cell death.
Adv Exp Med Biol.
1997;425:177-83.
Review. No abstract available.
PMID: 9433500
|
Salvesen
GS, Dixit VM.
Caspases: intracellular
signaling by proteolysis.
Cell. 1997 Nov 14;91(4):443-6.
Review.
No abstract available.
PMID: 9390553
|
Stennicke
HR, Salvesen GS.
Biochemical
characteristics of caspases-3, -6, -7, and -8.
J Biol Chem. 1997 Oct
10;272(41):25719-23.
PMID: 9325297
|
Caulin C, Salvesen GS, Oshima RG.
Caspase cleavage of
keratin 18 and reorganization of intermediate
filaments
during epithelial cell apoptosis.
J Cell Biol. 1997 Sep
22;138(6):1379-94.
PMID: 9298992
|
Ellerby HM, Martin SJ, Ellerby
LM,
Naiem SS, Rabizadeh S, Salvesen GS,
Casiano CA, Cashman NR, Green DR, Bredesen DE.
Establishment of a
cell-free system of neuronal apoptosis: comparison
of
premitochondrial, mitochondrial, and postmitochondrial phases.
J Neurosci. 1997 Aug
15;17(16):6165-78.
PMID: 9236228
|
Cardone MH, Salvesen GS, Widmann C, Johnson G,
Frisch
SM.
The regulation of
anoikis: MEKK-1 activation requires cleavage by
caspases.
Cell. 1997 Jul 25;90(2):315-23.
PMID: 9244305
|
Perry DK, Smyth MJ, Stennicke HR, Salvesen GS, Duriez P, Poirier GG,
Hannun
YA.
Zinc is a potent
inhibitor of the apoptotic protease, caspase-3. A
novel
target for zinc in the inhibition of apoptosis.
J Biol Chem. 1997 Jul
25;272(30):18530-3.
PMID: 9228015
|
Deveraux QL, Takahashi R, Salvesen GS, Reed JC.
X-linked IAP is a
direct inhibitor of cell-death proteases.
Nature. 1997 Jul
17;388(6639):300-4.
PMID: 9230442
|
Zhou
Q, Salvesen GS.
Activation of
pro-caspase-7
by serine proteases includes a
non-canonical
specificity.
Biochem J. 1997 Jun 1;324 ( Pt
2):361-4.
PMID: 9182691
|
Zhou
Q, Snipas S, Orth K,
Muzio M, Dixit VM, Salvesen GS.
Target protease
specificity of the
viral serpin CrmA. Analysis of five
caspases.
J Biol Chem. 1997 Mar
21;272(12):7797-800.
PMID: 9065443
|
Muzio M, Salvesen GS, Dixit VM.
FLICE induced apoptosis
in a cell-free system. Cleavage of caspase
zymogens.
J Biol Chem. 1997 Jan
31;272(5):2952-6.
PMID: 9006941
|
| 1996
Publications |
Koloczek H, Banbula A, Salvesen GS, Potempa J.
Serpin alpha
1proteinase inhibitor probed by intrinsic tryptophan
fluorescence
spectroscopy.
Protein Sci. 1996
Nov;5(11):2226-35.
PMID: 8931141
|
Froelich CJ, Hanna WL, Poirier
GG,
Duriez PJ, D'Amours D, Salvesen GS,
Alnemri ES, Earnshaw WC, Shah GM.
Granzyme
B/perforin-mediated
apoptosis of Jurkat cells results in
cleavage
of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and
less
abundant 64-kDa fragment.
Biochem Biophys Res Commun.
1996
Oct 23;227(3):658-65.
PMID: 8885990
|
Orth K, O'Rourke K, Salvesen GS, Dixit VM.
Molecular ordering of
apoptotic mammalian CED-3/ICE-like proteases.
J Biol Chem. 1996 Aug
30;271(35):20977-80.
PMID: 8702858
|
Komiyama
T, Gron H, Pemberton PA, Salvesen
GS.
Interaction of
subtilisins with serpins.
Protein Sci. 1996
May;5(5):874-82.
PMID: 8732759
|
Quan
LT, Tewari M, O'Rourke K, Dixit V, Snipas SJ, Poirier GG, Ray C, Pickup
DJ, Salvesen GS.
Proteolytic activation of
the
cell death protease Yama/CPP32 by
granzyme
B.
Proc Natl Acad Sci U S A. 1996
Mar
5;93(5):1972-6.
PMID: 8700869
|
Komiyama
T, Quan LT, Salvesen GS.
Inhibition of cysteine and
serine proteinases by the cowpox virus
serpin
CRMA.
Adv Exp Med Biol.
1996;389:173-6.
Review. No abstract available.
PMID: 8861008
|
| 1995
Publications |
Tewari M, Quan LT,
O'Rourke
K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM.
Yama/CPP32 beta, a
mammalian homolog of CED-3, is a CrmA-inhibitable
protease
that cleaves the death substrate poly(ADP-ribose) polymerase.
Cell. 1995 Jun 2;81(5):801-9.
PMID: 7774019
|
Quan LT, Caputo A,
Bleackley
RC, Pickup DJ, Salvesen GS.
Granzyme B is inhibited by
the cowpox virus serpin cytokine response
modifier
A.
J Biol Chem. 1995 May
5;270(18):10377-9.
PMID: 7737968
|
| 1993
Publications |
Strittmatter WJ, Weisgraber KH,
Huang
DY, Dong LM, Salvesen GS,
Pericak-Vance
M, Schmechel D, Saunders AM, Goldgaber D, Roses AD.
Binding of human
apolipoprotein E to synthetic amyloid beta peptide:
isoform-specific
effects and implications for late-onset Alzheimer disease.
Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8098-102.
PMID: 8367470
|
Strittmatter WJ, Saunders AM,
Schmechel
D, Pericak-Vance M, Enghild J, Salvesen
GS, Roses AD.
Apolipoprotein E:
high-avidity binding to beta-amyloid and increased
frequency
of type 4 allele in late-onset familial Alzheimer disease.
Proc Natl Acad Sci U S A. 1993
Mar
1;90(5):1977-81.
PMID: 8446617
|
| 1992
Publications |
Ray CA, Black RA, Kronheim SR,
Greenstreet
TA, Sleath PR, Salvesen GS,
Pickup
DJ.
Viral inhibition of
inflammation: cowpox virus encodes an inhibitor of
the
interleukin-1 beta converting enzyme.
Cell. 1992 May
15;69(4):597-604.
PMID: 1339309
|
Salvesen
G, Quan LT, Enghild JJ,
Snipas S, Fey GH, Pizzo
SV.
Expression of a
functional alpha-macroglobulin receptor binding domain
in
Escherichia coli.
FEBS Lett. 1992 Nov
23;313(2):198-202.
PMID: 1385222
|
| 1988
Publication |
Roche PA, Salvesen GS, Pizzo SV.
Symmetry of the
inhibitory unit of human alpha 2-macroglobulin.
Biochemistry. 1988 Oct
4;27(20):7876-81.
PMID: 2462911
|
| 1985
Publication |
Salvesen
GS, Catanese JJ, Kress LF, Travis J.
Primary structure of the
reactive site of human C1-inhibitor.
J Biol Chem. 1985 Feb
25;260(4):2432-6.
PMID: 3919001
|
| 1983
Publications |
Virca GD, Salvesen GS, Travis J.
Human neutrophil elastase
and cathepsin G cleavage sites in the bait
region
of alpha 2-macroglobulin. Proposed structural limits of the bait region.
Hoppe Seylers Z Physiol Chem.
1983
Sep;364(9):1297-302.
PMID: 6195065
|
Travis J, Salvesen GS.
Human plasma proteinase
inhibitors.
Annu Rev Biochem.
1983;52:655-709.
Review. No abstract available.
PMID: 6193754
|
| 1982
Publication |
Roberts RC, Nelles LP, Hall PK, Salvesen GS, Mischler E.
Comparison of the
structure and aspects of the proteinase-binding
properties
of cystic fibrotic alpha-macroglobulin with normal alpha
2-macroglobulin.
Pediatr Res. 1982
Jun;16(6):416-23.
PMID: 6179035
|
| 1981
Publication |
Salvesen
GS, Sayers CA, Barrett AJ.
Further characterization
of the covalent linking reaction of alpha
2-macroglobulin.
Biochem J. 1981 May
1;195(2):453-61.
PMID: 6172116
|
| 1980
Publication |
Salvesen
GS, Barrett AJ.
Covalent binding of
proteinases in their reaction with alpha
2-macroglobulin.
Biochem J. 1980 Jun
1;187(3):695-701.
PMID: 6204637
|
